2022 Illinois St Football Schedule
| Sep 3 | @Wisconsin Madison, WI | L 0-38 | ||
| Sep 10 | Valparaiso Normal, Ill. | W 28-21 | ||
| Sep 17 | Eastern Illinois Normal, Ill. | W 35-7 | ||
| Oct 1 |  | Southern Illinois Normal, IL | L 14-19 | |
| Oct 8 | @Northern Iowa Cedar Falls, Iowa | W 23-21 | ||
| Oct 15 |  | South Dakota Normal, Ill. | W 12-10 | |
| Oct 22 | @Indiana St Terre Haute, Ind. | W 27-21 | ||
| Oct 29 | @North Dakota St Fargo, N.D. | L 7-24 | ||
| Nov 5 | Youngstown St Normal, Ill. | L 17-19 | ||
| Nov 12 | @South Dakota St Brookings, S.D. | L 7-31 | ||
| Nov 19 | Western Illinois Normal, Ill. | W 20-13 |