2022 Indiana St Football Schedule
| Sep 1 | North Alabama Terre Haute, Ind. | W 17-14 | ||
| Sep 10 | @Purdue West Lafayette, IN | L 0-56 | ||
| Sep 17 | Montana Terre Haute, Ind. | L 14-49 | ||
| Oct 1 | @Northern Iowa Cedar Falls, Iowa | L 14-20 | ||
| Oct 8 | North Dakota St Terre Haute, Ind. | L 26-31 | ||
| Oct 15 | @Youngstown St Youngstown, OH | L 42-48 | ||
| Oct 22 | Illinois St Terre Haute, Ind. | L 21-27 | ||
| Oct 29 | @South Dakota St Brookings, S.D. | L 7-49 | ||
| Nov 5 |  | North Dakota Terre Haute, IN | L 7-42 | |
| Nov 12 | @Western Illinois Macomb, Illinois | W 21-0 | ||
| Nov 19 | Missouri St Terre Haute, Ind. | L 7-24 |