2022 Northern Iowa Football Schedule
| Sep 3 | @Air Force USAF Academy, CO | L 17-48 | ||
| Sep 10 |  | @North Dakota Alerus Center | L 27-29 | |
| Sep 17 | Sacramento St Cedar Falls, Iowa | L 21-37 | ||
| Sep 24 | @Western Illinois Macomb, IL | W 52-17 | ||
| Oct 1 | Indiana St Cedar Falls, Iowa | W 20-14 | ||
| Oct 8 | Illinois St Cedar Falls, Iowa | L 21-23 | ||
| Oct 15 | Dixie St Cedar Falls, Iowa | |||
| Oct 22 | Missouri St Cedar Falls, Iowa | W 41-20 | ||
| Oct 29 |  | @Southern Illinois Carbondale, IL | W 37-36 | |
| Nov 5 | South Dakota St Cedar Falls, Iowa | L 28-31 | ||
| Nov 19 |  | @South Dakota Vermillion, S.D. | W 58-14 |