2022 South Dakota St Football Schedule
| Sep 3 | @Iowa Iowa City, IA | L 3-7 | ||
| Sep 10 |  | UC-Davis Brookings, S.D. | W 24-22 | |
| Sep 17 | Butler Brookings, S.D. | W 45-17 | ||
| Sep 24 | @Missouri St Springfield | W 28-14 | ||
| Oct 1 | Western Illinois Brookings, S.D. | W 34-10 | ||
| Oct 8 |  | South Dakota Brookings, S.D. | W 28-3 | |
| Oct 15 | @North Dakota St Fargo, N.D. | W 23-21 | ||
| Oct 22 |  | @North Dakota Grand Forks, N.D. | W 49-35 | |
| Oct 29 | Indiana St Brookings, S.D. | W 49-7 | ||
| Nov 5 | @Northern Iowa Cedar Falls, Iowa | W 31-28 | ||
| Nov 12 | Illinois St Brookings, S.D. | W 31-7 | ||
| Dec 3 | Delaware Brookings, SD | W 42-6 | ||
| Dec 10 | Holy Cross Brookings, SD | W 42-21 | ||
| Dec 17 | Montana St Brookings, SD | W 39-18 | ||
| Jan 8 | @North Dakota St Frisco, Texas | W 45-21 | ||
| Jan 8 | North Dakota St Frisco, Texas | W 45-21 |