2022 Southern Illinois Football Schedule
| Sep 3 | @Incarnate Word San Antonio, TX | L 29-64 | ||
| Sep 10 | SE Missouri St Carbondale, IL | L 31-34 | ||
| Sep 17 | @Northwestern Evanston, IL | W 31-24 | ||
| Sep 24 |  | North Dakota Carbondale | W 34-17 | |
| Oct 1 | @Illinois St Normal, IL | W 19-14 | ||
| Oct 8 | @Missouri St Springfield, MO | W 38-21 | ||
| Oct 15 | Western Illinois Carbondale, IL | W 30-7 | ||
| Oct 22 |  | @South Dakota Vermillion, SD | L 24-27 | |
| Oct 29 | Northern Iowa Carbondale, IL | L 36-37 | ||
| Nov 12 | North Dakota St Carbondale, IL | L 18-21 | ||
| Nov 19 | @Youngstown St Youngstown, OH | L 21-28 |