2022 Western Illinois Football Schedule
| Sep 1 | @Tennessee-Martin Martin, TN | L 25-42 | ||
| Sep 10 | @Minnesota Minneapolis, MN | L 10-62 | ||
| Sep 17 |  | Southern Utah Macomb, Illinois | L 10-17 | |
| Sep 24 | Northern Iowa Macomb, IL | L 17-52 | ||
| Oct 1 | @South Dakota St Brookings, S.D. | L 10-34 | ||
| Oct 15 |  | @Southern Illinois Carbondale, IL | L 7-30 | |
| Oct 22 | Youngstown St Macomb, Illinois | L 27-28 | ||
| Oct 29 | @Missouri St Springfield | L 14-64 | ||
| Nov 5 | North Dakota St Macomb, Ill. | L 17-56 | ||
| Nov 12 | Indiana St Macomb, Illinois | L 0-21 | ||
| Nov 19 | @Illinois St Normal, Ill. | L 13-20 |