2022 Youngstown St Football Schedule
| Sep 3 | Duquesne Youngstown, OH | |||
| Sep 10 | Dayton Youngstown, OH | |||
| Oct 1 | @North Dakota St Fargo, N.D. | |||
| Oct 8 |  | North Dakota Youngstown, OH | ||
| Oct 15 | Indiana St Youngstown, OH | |||
| Oct 22 | @Western Illinois Macomb, Illinois | |||
| Oct 29 |  | South Dakota Youngstown, OH | ||
| Nov 5 | @Illinois St Normal, Ill. | |||
| Nov 12 | @Missouri St Springfield | |||
| Nov 19 |  | Southern Illinois Youngstown, OH |