2022 Youngstown St Football Schedule
| Sep 3 | Duquesne Youngstown, OH | W 31-14 | ||
| Sep 10 | Dayton Youngstown, OH | W 49-16 | ||
| Sep 17 | @Kentucky Lexington, KY | L 0-31 | ||
| Oct 1 | @North Dakota St Fargo, N.D. | L 14-27 | ||
| Oct 8 |  | North Dakota Youngstown, OH | L 30-35 | |
| Oct 15 | Indiana St Youngstown, OH | W 48-42 | ||
| Oct 22 | @Western Illinois Macomb, Illinois | W 28-27 | ||
| Oct 29 |  | South Dakota Youngstown, OH | W 45-24 | |
| Nov 5 | @Illinois St Normal, Ill. | W 19-17 | ||
| Nov 12 | @Missouri St Springfield | L 22-25 | ||
| Nov 19 |  | Southern Illinois Youngstown, OH | W 28-21 |