2021 Boston University Mens Hockey Schedule
| Oct 2 | 7:30 ET |  | Holy Cross | W 6-1 |
| Oct 8 | 7:05 ET |  | @Connecticut | W 2-1 |
| Oct 9 | 7:00 ET | | Connecticut | L 1-5 |
| Oct 15 | 7:30 ET |  | Sacred Heart | L 2-3 |
| Oct 16 | 7:00 ET | | Sacred Heart | W 4-1 |
| Oct 22 | 7:00 ET |  | @Merrimack | L 2-3 |
| Oct 23 | 7:00 ET | | Merrimack | W 8-6 |
| Oct 29 | 7:30 ET | UMass Lowell | L 0-3 | |
| Oct 29 | 7:30 ET |  | Mass.-Lowell | L 0-3 |
| Oct 30 | 6:05 ET | @UMass Lowell | L 1-2 | |
| Oct 30 | 6:05 ET | | @Mass.-Lowell | L 1-2 |
| Nov 5 | 6:37 ET |  | @Northern Michigan | L 3-5 |
| Nov 6 | 6:37 ET | | @Northern Michigan | L 2-6 |
| Nov 12 | 7:30 ET |  | Massachusetts | T 2-2 |
| Nov 13 | 7:00 ET | | @Massachusetts | W 4-3 |
| Nov 19 | 7:30 ET |  | Northeastern | L 0-1 |
| Nov 20 | 7:00 ET | | @Northeastern | T 2-2 |
| Nov 27 | 8:00 ET |  | @Cornell | L 4-6 |
| Dec 3 | 7:30 ET |  | New Hampshire | W 3-1 |
| Dec 4 | 7:00 ET | | @New Hampshire | W 2-1 |
| Dec 10 | 7:30 ET |  | Boston College | T 3-3 |
| Dec 11 | US Under-18 Team | L 3-4 | ||
| Dec 12 | 3:00 ET | US Under-18 Team | ||
| Dec 31 | 2:00 ET |  | @Brown | W 5-1 |
| Jan 7 | 7:30 ET | Arizona State | W 7-1 | |
| Jan 8 | 7:00 ET | Arizona State | W 5-2 | |
| Jan 14 | 7:05 ET | | @Connecticut | W 2-1 |
| Jan 21 | 7:00 ET |  | Vermont | L 1-2 |
| Jan 22 | 4:00 ET | | Vermont | W 4-0 |
| Jan 25 | 7:00 ET | | @Massachusetts | W 6-4 |
| Jan 30 | 4:00 ET |  | Providence | W 5-2 |
| Feb 4 | 7:30 ET |  | Maine | W 4-0 |
| Feb 7 | 5:00 ET |  | @Harvard | W 4-3 |
| Feb 11 | 7:00 ET | | @Providence | W 4-1 |
| Feb 14 | 4:30/7:30 ET | BC/Northeastern | ||
| Feb 14 | 7:30 ET | | @Northeastern | W 1-0 |
| Feb 25 | 7:00 ET | | @Boston College | |
| Feb 26 | 6:30 ET | | Boston College | W 6-3 |
| Feb 27 | 4:00 ET | | @Boston College | L 1-3 |
| Mar 4 | 7:30 ET | | @Maine | W 5-1 |
| Mar 5 | 7:00 ET | | @Maine | L 1-8 |
| Mar 12 | 4:30 ET | | @Connecticut | L 1-3 |