2022 Holy Cross Mens Hockey Schedule
| Oct 1 | 7:30 ET |  | Boston College | W 2-1 |
| Oct 7 | 7:07 CT |  | @North Dakota | |
| Oct 8 | 6:07 CT | | @North Dakota | |
| Oct 13 | 7:00 ET |  | Sacred Heart | |
| Oct 14 | 7:00 ET | | Sacred Heart | |
| Oct 18 | 7:05 ET |  | @American Int'l | |
| Oct 22 | 7:00 ET |  | @Vermont | |
| Oct 28 | 7:05 ET |  | @RIT | |
| Oct 29 | 4:05 ET | | @RIT | |
| Nov 4 | 7:00 ET |  | @Canisius | |
| Nov 5 | 4:00 ET | | @Canisius | |
| Nov 15 | 7:05 ET | | @American Int'l | |
| Nov 18 | 6:00 ET |  | Mercyhurst | |
| Nov 19 | 2:30 ET | | Mercyhurst | |
| Nov 22 | 4:00 ET |  | @Merrimack | |
| Nov 25 | 2:00 ET |  | @Brown | |
| Nov 26 | 7:00 ET |  | New Hampshire | |
| Dec 2 | 7:05 MT |  | @Air Force | |
| Dec 3 | 5:05 MT | | @Air Force | |
| Dec 30 | 7:00 ET |  | Quinnipiac | |
| Jan 7 | 4:00 ET |  | Clarkson | |
| Jan 13 | 7:00 ET | | Air Force | |
| Jan 14 | | Air Force | ||
| Jan 15 | 4:00 ET | | Air Force | |
| Jan 20 | 7:00 ET | | @Sacred Heart | |
| Jan 21 | 7:00 ET | | @Sacred Heart | |
| Jan 27 | 7:00 ET | | RIT | |
| Jan 28 | 7:00 ET | | RIT | |
| Feb 3 | 7:05 ET |  | @Bentley | |
| Feb 4 | 4:05 ET | | @Bentley | |
| Feb 10 | 7:00 ET |  | @Army | |
| Feb 11 | 4:00 ET | | @Army | |
| Feb 17 | 7:00 ET |  | Niagara | |
| Feb 18 | 7:00 ET | | Niagara | |
| Feb 24 | 7:00 ET | | Canisius | |
| Feb 25 | 7:00 ET | | Canisius |