2021 St. Lawrence Mens Hockey Schedule
| Oct 2 | 7:00 ET |  | @Clarkson | W 3-0 |
| Oct 8 | 7:07 MT |  | @Colorado College | W 2-1 |
| Oct 9 | 6:07 MT | | @Colorado College | T 1-1 |
| Oct 16 | 7:05 ET |  | @RIT | L 1-2 |
| Oct 29 | 7:07 ET |  | @Lake Superior | T 2-2 |
| Oct 30 | 6:07 ET | | @Lake Superior | L 1-7 |
| Nov 5 | 7:00 ET |  | @Rensselaer | W 4-3 |
| Nov 6 | 7:00 ET |  | @Union | T 2-2 |
| Nov 12 | 7:00 ET |  | Dartmouth | L 2-3 |
| Nov 13 | 7:00 ET |  | Harvard | T 1-1 |
| Nov 19 | 7:00 ET |  | @Princeton | W 6-4 |
| Nov 20 | 7:00 ET |  | @Quinnipiac | L 0-8 |
| Nov 26 | 7:00 ET |  | Western Michigan | L 2-8 |
| Nov 27 | 7:00 ET | | Western Michigan | L 1-5 |
| Dec 3 | 7:00 ET |  | Colgate | |
| Dec 3 | 7:00 ET |  | Cornell | L 1-4 |
| Dec 4 | 7:00 ET | | Cornell | |
| Dec 4 | 7:00 ET | | Colgate | W 4-3 |
| Dec 29 | 7:00 ET | UMass Lowell | ||
| Dec 29 | 7:00 ET |  | Mass.-Lowell | L 2-3 |
| Dec 31 | 7:00 ET |  | Nebraska-Omaha | W 3-2 |
| Jan 1 | 7:00 ET | | Nebraska-Omaha | L 0-5 |
| Jan 7 | CANC |  | @New Hampshire | |
| Jan 8 | CANC |  | @Merrimack | |
| Jan 14 | 7:00 ET | | Union | L 2-3 |
| Jan 15 | 7:00 ET | | Rensselaer | |
| Jan 17 | 3:00 ET | | Rensselaer | L 0-4 |
| Jan 21 | 7:00 ET | | @Harvard | L 1-4 |
| Jan 22 | 7:00 ET | | @Dartmouth | W 3-1 |
| Jan 28 | 7:00 ET | | @Clarkson | L 0-1 |
| Jan 29 | 7:00 ET | | Clarkson | T 4-4 |
| Feb 4 | 7:00 ET |  | @Yale | W 2-1 |
| Feb 5 | 7:00 ET |  | @Brown | T 1-1 |
| Feb 11 | 7:00 ET | | Quinnipiac | L 1-3 |
| Feb 12 | 7:00 ET | | Princeton | L 2-3 |
| Feb 18 | 7:00 ET | | @Cornell | W 2-1 |
| Feb 19 | 7:00 ET | | @Colgate | L 2-4 |
| Feb 25 | 7:00 ET | | Brown | T 1-1 |
| Feb 26 | 7:00 ET | | Yale | W 3-1 |
| Mar 4 | 7:00 ET | | Brown | W 4-1 |
| Mar 5 | 7:00 ET | | Brown | L 1-2 |
| Mar 6 | 4:00 ET | | Brown | W 4-3 |
| Mar 11 | 7:00 ET | | @Quinnipiac | L 1-4 |
| Mar 12 | 7:00 ET | | @Quinnipiac | L 3-4 |