2021 Minnesota-Duluth Mens Hockey Schedule
| Oct 3 | 1:00 CT |  | @Wisconsin | W 4-2 |
| Oct 8 | 7:07 CT |  | @Bemidji State | W 4-2 |
| Oct 9 | 7:07 CT | | Bemidji State | W 2-1 |
| Oct 15 | 7:37 CT |  | Michigan | L 1-5 |
| Oct 16 | 7:37 CT |  | Providence | W 3-2 |
| Oct 22 | 7:00 CT |  | @Minnesota | W 5-3 |
| Oct 23 | 7:07 CT | | Minnesota | W 2-1 |
| Nov 5 | 7:05 ET |  | @Western Michigan | L 3-4 |
| Nov 6 | 7:05 ET | | @Western Michigan | W 3-0 |
| Nov 12 | 7:07 CT |  | Colorado College | W 5-0 |
| Nov 13 | 7:07 CT | | Colorado College | T 0-0 |
| Nov 19 | 7:07 CT |  | @North Dakota | W 4-1 |
| Nov 20 | 6:07 CT | | @North Dakota | L 1-2 |
| Nov 26 | 7:07 CT |  | Alaska | W 5-1 |
| Nov 27 | 7:07 CT | | Alaska | W 1-0 |
| Dec 3 | 6:37 ET |  | @Northern Michigan | L 4-5 |
| Dec 4 | 6:37 ET | | @Northern Michigan | L 2-5 |
| Dec 10 | 7:07 CT |  | Denver | L 0-5 |
| Dec 11 | 7:07 CT | | Denver | W 6-2 |
| Dec 30 | 7:07 CT |  | @MSU-Mankato | L 1-2 |
| Jan 1 | 7:07 CT | | MSU-Mankato | L 0-3 |
| Jan 7 | PPD |  | @St Cloud St | |
| Jan 8 | PPD | | @St Cloud St | |
| Jan 14 | 7:07 CT |  | Miami | W 4-1 |
| Jan 15 | 7:07 CT | | Miami | T 2-2 |
| Jan 21 | 7:07 CT |  | @Nebraska-Omaha | W 5-1 |
| Jan 22 | 6:07 CT | | @Nebraska-Omaha | L 1-5 |
| Jan 28 | 7:07 CT | | Western Michigan | W 5-4 |
| Jan 29 | 7:07 CT | | Western Michigan | L 2-3 |
| Feb 8 | 6:07 CT | | @St Cloud St | T 2-2 |
| Feb 11 | 7:07 MT | | @Denver | L 3-5 |
| Feb 12 | 6:07 MT | | @Denver | W 3-2 |
| Feb 18 | 7:30 CT | | North Dakota | L 3-4 |
| Feb 19 | 7:07 CT | | North Dakota | L 2-3 |
| Feb 22 | 6:07 CT | | @St Cloud St | T 1-1 |
| Feb 25 | 7:05 ET | | @Miami | W 3-1 |
| Feb 26 | 5:05 ET | | @Miami | L 0-4 |
| Mar 4 | 7:30 CT | | St Cloud St | W 3-2 |
| Mar 5 | 7:07 CT | | St Cloud St | L 0-2 |
| Mar 11 | 7:07 CT | | @St Cloud St | W 5-2 |
| Mar 12 | 6:07 CT | | @St Cloud St | W 4-3 |
| Mar 18 | 4:07 CT | | @Denver | W 2-0 |
| Mar 19 | 7:37 CT | @WMU/North Dakota | ||
| Mar 19 | 7:37 CT | | @Western Michigan | W 3-0 |
| Mar 24 | 1:00 MT |  | Michigan Tech | W 3-0 |
| Mar 26 | 2:00 MT | @UML/Denver | ||
| Mar 26 | 2:00 MT | | @Denver | L 1-2 |