2021 Minnesota Mens Hockey Schedule
| Oct 8 | 7:00 CT |  | Mercyhurst | W 7-4 |
| Oct 9 | 5:00 CT | | Mercyhurst | W 5-3 |
| Oct 15 | 7:00 CT |  | St Cloud St | L 1-2 |
| Oct 16 | 5:07 CT | | @St Cloud St | W 4-3 |
| Oct 22 | 7:00 CT | Minnesota Duluth | L 3-5 | |
| Oct 22 | 7:00 CT |  | Minnesota-Duluth | L 3-5 |
| Oct 23 | 7:07 CT | @Minnesota Duluth | L 1-2 | |
| Oct 23 | 7:07 CT | | @Minnesota-Duluth | L 1-2 |
| Oct 29 | 8:00 CT |  | Notre Dame | W 4-1 |
| Oct 30 | 5:00 CT | | Notre Dame | W 3-2 |
| Nov 5 | 7:00 CT |  | @Wisconsin | L 3-4 |
| Nov 6 | 8:00 CT | | @Wisconsin | W 4-1 |
| Nov 12 | 6:30 CT |  | Ohio State | L 3-4 |
| Nov 13 | 5:00 CT | | Ohio State | W 2-0 |
| Nov 19 | 7:00 CT |  | Penn State | L 3-5 |
| Nov 20 | 8:00 CT | | Penn State | W 4-2 |
| Nov 26 | 7:07 CT |  | @North Dakota | W 5-1 |
| Nov 27 | 6:07 CT | | @North Dakota | L 2-3 |
| Dec 3 | 6:30 ET |  | @Michigan | W 5-1 |
| Dec 4 | 7:00 ET | | @Michigan | L 2-6 |
| Jan 2 | St. Thomas | W 5-2 | ||
| Jan 3 | 6:00 CT | US Under-18 Team | W 5-3 | |
| Jan 7 | 6:30 ET |  | @Michigan State | W 4-1 |
| Jan 8 | 7:30 ET | | @Michigan State | W 6-3 |
| Jan 14 | 6:00 CT |  | Alaska | W 4-1 |
| Jan 15 | 6:00 CT | | Alaska | L 2-3 |
| Jan 21 | 8:00 CT | | Michigan | W 2-1 |
| Jan 22 | 6:30 CT | | Michigan | L 1-4 |
| Jan 28 | 7:30 ET | | @Notre Dame | W 5-1 |
| Jan 29 | 6:00 ET | | @Notre Dame | L 2-3 |
| Feb 4 | 7:00 CT | | Michigan State | W 4-2 |
| Feb 5 | 5:00 CT | | Michigan State | W 3-1 |
| Feb 11 | 6:00 ET | | @Ohio State | W 3-2 |
| Feb 12 | 6:00 ET | | @Ohio State | W 5-1 |
| Feb 18 | 6:30 ET | | @Penn State | W 3-1 |
| Feb 19 | 6:00 ET | | @Penn State | W 6-4 |
| Feb 25 | 8:00 CT | | Wisconsin | W 5-0 |
| Feb 26 | 7:00 CT | | Wisconsin | W 8-0 |
| Mar 12 | 8:00 CT | | Penn State | W 3-2 |
| Mar 19 | 7:00 CT | | Michigan | L 3-4 |
| Mar 25 | 6:00 ET |  | Massachusetts | W 4-3 |
| Mar 27 | 4:00 ET |  | @Western Michigan | W 3-0 |
| Apr 7 | 8:30 ET |  | @MSU-Mankato | L 1-5 |