2025 Southern Illinois Football Schedule
| Aug 30 | Thomas More Carbondale, IL | W 49-3 | ||
| Sep 6 | @Purdue West Lafayette, IN | L 17-34 | ||
| Sep 13 | @Tennessee-Martin Martin, TN | W 37-10 | ||
| Sep 20 | @SE Missouri St Cape Girardeau, MO | W 59-31 | ||
| Oct 4 | Indiana St Carbondale, Ill. | W 55-27 | ||
| Oct 11 | @North Dakota St Fargo, ND | L 17-45 | ||
| Oct 18 |  | North Dakota Carbondale, IL | L 19-38 | |
| Oct 25 | Northern Iowa Carbondale, IL | W 31-17 | ||
| Nov 1 | @Murray St Murray, Ky. | W 27-7 | ||
| Nov 8 | @Youngstown St Youngstown, OH | L 38-48 | ||
| Nov 15 |  | South Dakota Carbondale, IL | ||
| Nov 22 | @Illinois St Normal, IL |