2025 Southern Illinois Football Schedule
| Aug 30 | Thomas More Carbondale, IL | W 49-3 | ||
| Sep 6 | @Purdue West Lafayette, IN | |||
| Sep 13 | @Tennessee-Martin Martin, TN | |||
| Sep 20 | @SE Missouri St Cape Girardeau, MO | |||
| Oct 4 | Indiana St Carbondale, Ill. | |||
| Oct 11 | @North Dakota St Fargo, ND | |||
| Oct 18 |  | North Dakota Carbondale, IL | ||
| Oct 25 | Northern Iowa Carbondale, IL | |||
| Nov 1 | @Murray St Murray, Ky. | |||
| Nov 8 | @Youngstown St Youngstown, OH | |||
| Nov 15 |  | South Dakota Carbondale, IL | ||
| Nov 22 | @Illinois St Normal, IL |