2023 Southern Illinois Football Schedule
| Sep 2 | Austin Peay Carbondale, IL | W 49-23 | ||
| Sep 9 | @Northern Illinois DeKalb, IL | W 14-11 | ||
| Sep 30 | Missouri St Carbondale, IL | W 33-20 | ||
| Oct 7 | @Youngstown St Youngstown, OH | L 3-31 | ||
| Oct 21 | South Dakota St Carbondale, IL | L 10-17 | ||
| Oct 28 | @Western Illinois Macomb, IL | W 63-0 | ||
| Nov 4 |  | South Dakota Carbondale, IL | L 7-14 | |
| Nov 11 | @North Dakota St Fargo, N.D. | L 10-34 | ||
| Nov 18 | Indiana St Carbondale, IL | W 38-9 | ||
| Nov 25 | Nicholls St Carbondale, IL | W 35-0 | ||
| Dec 2 | @Idaho Moscow, ID | L 17-20 |